Immunology
Programme sponsor
Regulatory lymphoyctes in transplantation
HLA disease associations – ankylosing spondylitis and coeliac disease
HLA disease associations – ankylosing spondylitis and coeliac disease
Immunology
Abstract
This presentation will cover:
- An introduction to HLA
- An overview of HLA testing in Ankylosing Spondylitis and Coeliac Disease
- Describe the proposed mechanisms of HLA B27 in Ankylosing Spondylitis
- Describe the involvement of HLA DQ in Coeliac Disease
Speakers
Dr Nicola Speirs
UK NEQAS and BSHI guideline: Laboratory testing and clinical interpretation of HLA genotyping results supporting the diagnosis of coeliac disease
UK NEQAS and BSHI guideline: Laboratory testing and clinical interpretation of HLA genotyping results supporting the diagnosis of coeliac disease
Immunology
Abstract
The lecture will share details of why UK NEQAS created a test of guidelines to inform genetic testing in the diagnosis of Coeliac Disease. It will include information on the contents of the guidelines, the impact and the benefits of collaboration in EQA.
Speakers
Amy De’Ath
C1 esterase inhibitor (C1INH) defi ciency – innovative approaches to the management of a rare condition
Functional plasma kallikrein assay as a diganostic tool for bradykinin-mediated angioedema
Functional plasma kallikrein assay as a diganostic tool for bradykinin-mediated angioedema
Immunology
Learning Outcomes
The learning outcomes for this lecture will include:
1. Overview of Hereditary Angioedema (HAE) and its Classifications:
This lecture will provide an in-depth understanding of Hereditary Angioedema (HAE), including the various clinical classifications of the disease. Specific focus will be given to HAE with normal C1 esterase inhibitor (HAE-nC1-INH), a subtype characterised by normal C1-INH levels. The audience will be introduced to recent discoveries of genetic mutations associated with HAE-nC1-INH, expanding the understanding of its underlying molecular mechanisms.
2. Emerging Biomarkers in HAE:
The audience will gain insight into ongoing research aimed at identifying novel biomarkers involved in HAE pathophysiology. This lecture will focus on how these biomarkers could be used to improve HAE diagnosis and patient management, particularly in cases of HAE-nC1-INH where traditional diagnostic markers (such as C1-INH levels) are inconclusive.
3. The Role of Plasma Kallikrein in the Contact System Pathway:
The lecture will also explore the role of plasma kallikrein in the contact system pathway and how its dysregulation contributes to the pathophysiology of HAE. The interaction between plasma kallikrein and other components of the bradykinin pathway will be discussed and the audience will learn how this relates to the clinical manifestations of HAE
4. Plasma Kallikrein Assay as a Diagnostic Tool:
The lecture will cover the potential use of a plasma kallikrein assay as a diagnostic biomarker for HAE-nC1-INH. The lecture will present a proposed methodology for measuring activated plasma kallikrein. Patient data from this proposed assay, comparing different types of HAE will be reviewed, illustrating the potential use of this assay for differentiating HAE subtypes and assessing HAE patients on treatment.
Speakers
Ellie Gerred
Anti-tumour necrosis factor (TNF) drugs/ antibodies – an external quality assessment perspective
Validation of a new diagnostic testing pathway for systemic autoimmune rheumatic disease in primary and secondary care
Iterative improvement of monoclonal gammopathy of undetermined signifi cance (MGUS) monitoring and functionality for the EXTENT system
New uses for flow cytometry in clinical immunology
Newborn screening for severe combined immunodeficiency: The role of the flow cytometry laboratory
Antinuclear antibodies: current practice and impact of International Consensus on Antinuclear Antibody Patterns (ICAP) nomenclature
HSD management case: The evaluation of the Svar functional complement assay on the Dynex DS2
Intrathecal inflammation, the neuroimmunology lab’s role
Intrathecal inflammation, the neuroimmunology lab’s role
Immunology
Learning outcomes
Delegates will understand the:
- The clinical lab's role in diagnosis of neuroinflammatory conditions such as multiple sclerosis.
- The use of isoelectric focussing, hyperbolic reference curves and nephelometry.
- Future developments of CSF analysis for neuroinflammation
Speakers
Nicholas Armfield
Life’s good, it’s the disease that’s the problem
Life’s good, it’s the disease that’s the problem
Immunology
An inspirational true story about love, courage and determination delivered by award winning, philanthropic author Hazel Carter.
It was devastating news when Hazel’s husband, Alan, was told he had incurable motor neurone disease (MND) at age 62, but the disease did not stop the couple in their tracks.
Learn how they reacted to diagnosis, the drug trials Alan went on, and how the mindset the couple adopted enabled them to stay strong and enjoy some amazing adventures, even when Alan became 100% paralysed.
Speakers
Hazel Carter
Opening and Closing Plenary programmes
