Haematology
Morphology quiz
Haematology
Morphology quiz
9am – 10am BST, 23 September 2025 ‐ 1 hour
Haematology
Abstract
Learning outcomes
Speakers
Dr Michelle Brereton
Chief Biomedical Scientist, Manchester University NHS Foundation Trust
What is sickle cell disease?
Haematology
What is sickle cell disease?
10.30am – 11am BST, 23 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Professor Barbara Bain
Professor of Diagnostic Haematology, St Mary's Imperial College Healthcare NHS Trust
Immunophenotyping cases
Haematology
Immunophenotyping cases
11am – 11.30am BST, 23 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Clash of the Titans’ – WHO vs ICC case studies and panel discussion
Haematology
Clash of the Titans’ – WHO vs ICC case studies and panel discussion
11.30am – 12pm BST, 23 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Speakers
Professor Barbara Bain
Professor of Diagnostic Haematology, St Mary's Imperial College Healthcare NHS Trust
Dr Michelle Brereton
Chief Biomedical Scientist, Manchester University NHS Foundation Trust
Reversal of anticoagulation: How the lab can make a difference
Haematology
Reversal of anticoagulation: How the lab can make a difference
9am – 9.30am BST, 24 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Exploring novel biomarkers in multiple myeloma
Haematology
Exploring novel biomarkers in multiple myeloma
9.30am – 10am BST, 24 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Speakers
Can we use biomarkers to predict cancer-associated thrombosis?
Haematology
Can we use biomarkers to predict cancer-associated thrombosis?
10.30am – 11am BST, 24 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
FVII/FVIIa in preeclampsia
Haematology
FVII/FVIIa in preeclampsia
11am – 11.30am BST, 24 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Gene therapy and novel therapies in haemophilia in the era of precision medicine
Haematology
Gene therapy and novel therapies in haemophilia in the era of precision medicine
11.30am – 12pm BST, 24 September 2025 ‐ 30 mins
Haematology
Speakers
Dr Rashid Kazmi
Consultant Haematologist, University Hospital Southampton NHS Foundation Trust
Next-generation flow cytometry for minimum residual disease monitoring
Haematology
Next-generation flow cytometry for minimum residual disease monitoring
2pm – 2.30pm BST, 24 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Speakers
Heparin-induced thrombocytopenia (HIT) versus thrombotic thrombocytopenic purpura (TTP): A clinical case study
Haematology
Heparin-induced thrombocytopenia (HIT) versus thrombotic thrombocytopenic purpura (TTP): A clinical case study
2.30pm – 3pm BST, 24 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Speakers
When multiple inherited red cell disorders lead to severe anaemia – a case study
Haematology
When multiple inherited red cell disorders lead to severe anaemia – a case study
3pm – 3.30pm BST, 24 September 2025 ‐ 30 mins
Haematology
Abstract
Sickle cell disease is a monogenetic disorder caused by a mutation in the beta-chain of haemoglobin that leads to the generation of sickle haemoglobin(HbS) which, post deoxygenation state, undergoes polymerisation causing vaso-occlusion crisis .
Voxelotor, a recently approved novel therapeutic agent, modulates the Hb’s affinity for oxygen and thus increases the proportion of oxygenated Hb. This reduces the polymerisation of HbS and reduces the formation of sickle cells. Drug trials have demonstrated that Voxelotor leads an improvement in Hb level with decreased reticulocytes, bilirubin, LDH and decrease the frequency of sickle cell crisis.
One approach to monitor Voxelotor treatment is by quantifying HbS in the laboratory either by high performance of liquid chromatography(HPLC) or Capillary electrophoresis(CE). The aim of this study to assess influence of Voxelotor on the HPLC or CE chromatogram, electrophoregram respectively on HbS(%) level and the impact it can have on the management of the patient.
Analysis of patient blood on Biorad HPLC showed the appearance of a split band of HbS and D impacting significantly on HbS level. This will lead to reporting of lower level of HbS which will have impact on patient clinical management. When the same patient blood sample was analysed on Tosoh-G11 HPLC there was a split band of HbS and HbC but this time the impact was not significant on the HbS. In addition, when the same patient sample was analysed on the Sebia Minicap Capillary electrophoresis similar observation was made that a split band of HbS and another peak of varying level. If the HbS peak were reported as the total HbS level without including the modified HbS peak, then it could mitigate the total level of HbS% (underestimation) which may not instigate appropriate clinical management.
This study concludes that with patients on Voxelotor, HbS level evaluation may require HbS peak manipulation prior to reporting accurate total level of HbS% thus minimizing the impact of Voxelotor on the HbS level reporting. This will trigger as required appropriate clinical intervention.
Speakers
Advanced Roles
Haematology
Advanced Roles
4pm – 4.30pm BST, 24 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Exams in Haematology: Advancing your career
Haematology
Exams in Haematology: Advancing your career
4.30pm – 5pm BST, 24 September 2025 ‐ 30 mins
Haematology
Abstract
Speakers
Unstable haemoglobin
Haematology
Unstable haemoglobin
9am – 9.30am BST, 25 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Dr Sukhjinder Marwah
Senior Biomedical Scientist in Haemoglobinopathy, Royal Wolverhampton NHS Trust
Total B12 or not total B12? That is the question (NICE)
Haematology
Total B12 or not total B12? That is the question (NICE)
9.30am – 10am BST, 25 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Reticulocyte haemoglobin EQA programme: Two years and still counting
Haematology
Reticulocyte haemoglobin EQA programme: Two years and still counting
10.30am – 11am BST, 25 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
An interesting case study of childhood malaria in East Kent
Haematology
An interesting case study of childhood malaria in East Kent
11am – 11.30am BST, 25 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Learning the lessons from blood and blunders
Haematology
Learning the lessons from blood and blunders
11.30am – 12pm BST, 25 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Speakers
Rev Dr Gordon Sinclair
Senior Lecturer in Biomedical Science , London Metropolitan University
Meet The Experts: Haematology
Haematology
Meet The Experts: Haematology
12.45pm – 2pm BST, 25 September 2025 ‐ 1 hour 15 mins
Haematology
Bone marrow disorders
Haematology
Bone marrow disorders
2pm – 2.30pm BST, 25 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Speakers
Dr Fiona Clark
Consultant Haematologist, University Hospitals of North Midlands NHS Trust
The importance of the laboratory in diagnosis and research in anti -PF4 mediated thrombotic thrombocytopenic syndromes
Haematology
The importance of the laboratory in diagnosis and research in anti -PF4 mediated thrombotic thrombocytopenic syndromes
2.30pm – 3pm BST, 25 September 2025 ‐ 30 mins
Haematology
Abstract
Learning outcomes
Speakers
Is the future of full blood count testing in sight?
Haematology
Is the future of full blood count testing in sight?
3pm – 3.30pm BST, 25 September 2025 ‐ 30 mins
Haematology
Learning outcomes
Speakers
Opening and Closing Plenary programmes