Clinical Chemistry
Biomarkers of neurodegenerative disease
Clinical Chemistry
Biomarkers of neurodegenerative disease
9am – 9.30am BST, 23 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
This presentation will cover
- The emergence of biomarkers of neurodegenerative disease
- Biomarkers of neurological damage
- Biomarkers in Multiple Sclerosis & Motor Neuron Disease
- Biomarkers in Alzheimer’s, Dementia and Parkinson's Disease
- Current & future relevance in diagnosis and prognosis of neurological disease
Speakers

The curious case of microplastics and their journey to the centre of the gut
Clinical Chemistry
The curious case of microplastics and their journey to the centre of the gut
9.30am – 10am BST, 23 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
Microplastic (MP) exposure to humans is estimated at <168,000 environmental MP per day. Oral exposure risk is not well understood, specifically within the gastrointestinal tract (GIT) environment. Observations of inflammation, down regulation of cell growth, metabolic disruption and reactive oxygen species post MP exposure to GIT models. But studies have used limited primary polymer MP. These MP types are not wholly representative of human MP exposure. Limited studies have incorporated digestive fluid and the release components within MP and associated toxicity. This study aims to address some of these knowledge gaps. MP test material was created using a cryogenic abrasion method from polymer and plastic mix polyethylene terephthalate (PET) plastics.
MP produced had a mean diameter between 22-55 µm being fragmented in shape; similar to environmental MP. Aluminium (Al) contaminated and non-contaminated type was created. Caco-2 and HT29-MTX cells were exposed to MP test materials for growth curves and transcriptomic analysis to determine toxicity. MP test material was exposed to digestive fluid model to determine metal leachates. Growth curves observed significant reduction at the highest concentration; 0.5-1 mg/mL, with a dose dependent reduction, even at lower concentrations while not significant.
Transcriptomic analysis confirmed there was a down regulation of proliferation genes but also transcription related, cell function, signalling, transport membrane proteins, mucus production and the up regulation of some cytokine and oxidative stress genes. GSEA pathway highlighted cell junction, adhesion and function pathways were affected; mostly in caco-2 cells. Metal leachates in digestive fluid was analysed using ICP-MS. The stomach showed significant release of metals.
Al contaminated MP released the largest amount of associated metal. Exposure from PET MPs within in vitro monoculture caco-2 and HT29-MTX cells suggests reducing cell growth. Metals were leached from PET MPs and PET pre-loaded Al MPs are capable of leaching, suggesting that particle can be a vector for contaminants posing PET MPs could be a multi-level risk factor.
Speakers
The influence of folate supplementation during pregnancy on gestational diabetes and fetal outcomes
Clinical Chemistry
The influence of folate supplementation during pregnancy on gestational diabetes and fetal outcomes
10.30am – 11am BST, 23 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
This presentation will discuss:
- Folate - a brief overview
- Folate status in pregnancy
- Adverse effects in pregnancy including links to diabetes mellitus.
Speakers
Dr Agata Sobczyńska- Malefora
Consultant Clinical Scientist, Synnovis, St Thomas’ Hospital
Investigating infertility and supporting assisted conception services
Clinical Chemistry
Investigating infertility and supporting assisted conception services
11am – 11.30am BST, 23 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
Infertility is a complex, multifactorial condition affecting a significant portion of the global population, with many factors contributing to its prevalence. Clinical chemistry plays a crucial role in the diagnostic evaluation and management of infertility, providing essential biochemical insights that guide safe, personalised treatment protocols that optimise each couples chance of success.
Ahead of any IVF cycle, a series of tests are performed to assess general health, fertility potential, and any underlying medical conditions that could affect treatment outcomes. For women, key tests include hormonal profiling to evaluate ovarian reserve, such as Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), estradiol (E2), and anti-Müllerian hormone (AMH). Thyroid function (TSH, free T4), blood glucose and insulin resistance tests may also be conducted to identify conditions which may affect fertility and ovarian stimulation response.
For men, semen analysis is performed to assess sperm quality, including sperm count, motility, and morphology. Hormonal evaluations, such as testosterone and prolactin, may also be carried out if male infertility is suspected. Pre-IVF infectious disease screening is mandatory for both partners and includes tests for HIV, hepatitis B, hepatitis C for both the health of the patients, ongoing pregnancies and adherence to regulatory compliance for gamete/embryo storage. IVF cycles with donor gametes require an additional level of screening.
Throughout the IVF cycle, hormone levels are continually assessed to monitor ovarian response to stimulation alongside ultrasound tracking to measure follicular development and timing for the egg collection procedure. Human chorionic gonadotropin (hCG) is measured to confirm pregnancy after embryo transfer, and progesterone levels are monitored to ensure proper luteal phase support for the developing pregnancy. For recurrent pregnancy loss, immune tests and Thrombophilia screens may be employed.
Accurate interpretation of clinical chemistry tests is therefore essential for optimising IVF success rates and managing any potential complications during a treatment cycle.
Learning outcomes
Delegates will:
- Understand the interpretation and use of laboratory tests in the investigation of infertility and for assisted conception/IVF
- Gain knowledge on the patient perspective of assisted conception and IVF
- Understand how laboratory medicine supports embryology
Speakers

Placental-like growth factor (PlGF) and soluble fmslike tyrosine kinase 1 (sFlt) testing for pre-eclampsia
Clinical Chemistry
Placental-like growth factor (PlGF) and soluble fmslike tyrosine kinase 1 (sFlt) testing for pre-eclampsia
11.30am – 12pm BST, 23 September 2025 ‐ 30 mins
Clinical Chemistry
Learning outcomes
Delegates will learn:
- What PlGF and sFlt are
- How they were identified
- How they can be used in relation to diagnosing pre-eclampsia
- Why it is important to identify pre-eclampsia
- How using PlGF and sFlt to diagnose pre-eclampsia compares to other current methods, and what this means for the patients
Speakers

Professor Tim James
Head Biomedical Scientist, Oxford University Hospitals NHS Foundation Trust
Capillary testing: Operational considerations for a clinical laboratory
Clinical Chemistry
Capillary testing: Operational considerations for a clinical laboratory
9am – 9.30am BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
Venesection is still considered the gold standard for blood sample collection and remains one of the most performed medical procedures within the clinical setting. However, the need for specialist personnel and equipment makes this process resource-heavy, which can be a limiting factor.
Self-collected capillary blood sampling, the process of capturing small volumes of capillary blood (typically <500 µL), either using finger prick or transdermal collection devices, has been proven to be a viable alternative to venepuncture and could well be a significant contributor to a more patient-centric, personalized, cost-efficient healthcare system; focussed on patient participation and disease preventive. Given that up to 90% of a blood test's carbon footprint is related to the sample collection process, e.g., phlebotomy, capillary blood testing could also significantly reduce the environmental impact of the blood collection process.
Capillary blood collection kits use less plastic and therefore produce less waste. In addition, self-collection kits can be delivered to the patient and returned to the laboratory by the postal service, using highly efficient and ready-to-go postal and laboratory infrastructure.
The use of this technology can vastly reduce the need to visit a clinical setting while still utilizing high-quality, state-of-the-art laboratory services. However, issues remain in its deployment, including the comparability of capillary and venous samples, sample stability, patient preference, and the ability to include a large number of these samples into the routine laboratory workflow. Here we discuss our laboratory's approach, from utilizing the latest innovations in capillary blood collection, devising comparability and stability studies, to incorporating this sample type into the laboratory testing pathway.
Learning outcomes
Delegates will be able to:
- Describe operational and logistical factors for laboratories utilising capillary blood samples
- Discuss UKAS considerations for laboratory testing of capillary blood samples
Speakers
Faecal Immunochemistry Testing (FIT)
Clinical Chemistry
Faecal Immunochemistry Testing (FIT)
9.30am – 10am BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
This presentation will cover
- FIT testing in the context of Colorectal Cancer
- National screening pathway
- GP symptomatic referral pathway
- Methodology and equipment
- Standardisation and quality assurance
- Impact on colorectal cancer services
Speakers

Dr Sally Benton FRCPath
Consultant Clinical Biochemist and Director Bowel Cancer Screening Southern Hub, Berkshire and Surry Pathology Services
Home sampling: Applications and challenges for the laboratory
Clinical Chemistry
Home sampling: Applications and challenges for the laboratory
10.30am – 11am BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
This presentation will discuss:
- Improving access to healthcare
- Capillary blood sampling options for the laboratory
- Challenges and opportunities
Speakers

Professor Timothy McDonald
Clinical Director, Pathology Services, Royal Devon University Healthcare NHS Foundation Trust
Pregnancy in bariatric surgery patients and unique clinical Biochemistry considerations
Clinical Chemistry
Pregnancy in bariatric surgery patients and unique clinical Biochemistry considerations
11am – 11.30am BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
Pregnancy after bariatric surgery is different from a normal pregnancy as the fetus can be growing in a metabolic milieu which is impacted by surgery related malabsorption as a result of altered anatomy, physiology and biochemistry. In suboptimized patient with undiagnosed/poorly managed micronutrient deficiencies, there can be a huge risk of maternal and fetal complications.
Laboratory staff play a huge role in timely diagnosis and management of these patients by the clinical teams. There is huge paucity of information about this in general, with very limited exposure to medics and scientist in their regular training curriculums. Additionally, with medical tourism we are seeing a surge of patients having bariatric surgeries outside the UK , which can be non-standardised and pose huge risk to the mother and fetus. This talk is aimed to enhance medical and scientific awareness of laboratory professionals, who can directly /indirectly impact patient and fetal wellbeing as pregnant bariatric surgery patients are not limited to bariatric surgery units, but they can present to all departments in the hospital, including obstetrics and Gynae, A&E, cardiology, acute care unit and intensive care units.
Learning outcomes
Gain an insight into the challenges faced by clinicians when caring for bariatric patients post surgery. Including dietary considerations to ensure that sufficient minerals and vitamins are available to mother and baby.
Speakers
Changing diagnostic pathways in ovarian cancer - learning from the SONATA study
Clinical Chemistry
Changing diagnostic pathways in ovarian cancer - learning from the SONATA study
11.30am – 12pm BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
My talk will discuss innovative ways of evaluating diagnostic tests using routine NHS laboratory samples and data, the challenges of implementing diagnostic tests in practice and our insights from evaluating a threshold dependent integrated pathway change from primary care through to tertiary care.
Learning outcomes
Delegates will:
- Understand current use of CA125 as recommended by NICE for the detection of Ovarian cancer.
- Understand the unmet needs the detection of Ovarian Cancer.
- Understand the findings of the SONATA study (NHS England funded) into the utility of ROMA (CA125 +HE4) as a potential new tool to detect ovarian cancer early.
Speakers

Professor Sudha Sundar MPhil, MRCOG
Professor of Gynaecological Cancer, University of Birmingham
Meet the Specialist Advisory Panel: Clinical Chemistry
Clinical Chemistry
Meet the Specialist Advisory Panel: Clinical Chemistry
12.45pm – 1.45pm BST, 24 September 2025 ‐ 1 hour
Clinical Chemistry
This session allows the attendees to ask the clinical chemistry panel questions on a range of topics, such as IBMS qualifications, CPD, career advice etc.
Speakers


Martin McFadden
Diagnostic Programme Manager, South Tyneside and Sunderalnd NHS Foundation Trust

Lee Peters MSc CSci FIBMS
Blood Science Service Manager, Hywel Dda University Health Board
GP liaison: Pathology demand management
Clinical Chemistry
GP liaison: Pathology demand management
2pm – 2.30pm BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Learning outcomes
Delegates will understand how integrating disparate data sets can:
- Improve right-first-time diagnostics
- Reduce unwarranted variation
- Streamline processes to achieve faster and more reliable patient diagnoses.
Speakers
Higher Specialist Diploma case study: BRILS reagent shortage for free thyroxine
Clinical Chemistry
Higher Specialist Diploma case study: BRILS reagent shortage for free thyroxine
2.30pm – 3pm BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Learning outcomes
Through the discussion of a case study delegates will learn how a laboratory created a contingency plan for a unexpected reagent shortage and assessed the logistical and clinical impact of the shortage.
Speakers

Higher specialist diploma case study: A case of consistently elevated vitamin B12
Clinical Chemistry
Higher specialist diploma case study: A case of consistently elevated vitamin B12
3pm – 3.30pm BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
Through the discussion of his case study the presenter will:
- Describe how a new IQC monitoring solution was implemented
- Review success of implementation and lessons learned.
- Reflect on IQC monitoring in clinical laboratories
Speakers
Diabetic Ketoacidosis in type 2 diabetes – a consequence of treatment
Clinical Chemistry
Diabetic Ketoacidosis in type 2 diabetes – a consequence of treatment
4pm – 4.30pm BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
This talk will provide a brief overview of type 2 diabetes and current treatment strategies.
It will discuss the acute complication of Diabetic Ketoacidosis and how this can develop as a result of Sodium-Glucose Cotransporter 2 Inhibitors.
Speakers

Sheri Scott CSci FIBMS SFHEA
Principal Lecturer in Biomedical Science and IBMS Council Member, Nottingham Trent University
Clinical chemistry EQA report interpretation
Clinical Chemistry
Clinical chemistry EQA report interpretation
4.30pm – 5pm BST, 24 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
Speakers

Acute kidney injury and alerting
Clinical Chemistry
Acute kidney injury and alerting
9am – 9.30am BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
This presentation will cover
- AKI background
- GIRFT and AKI survey
- National recommendations
Speakers
Dr Rachel Marrington
Consultant EQA Scientist & Deputy Director, Birmingham Quality (UK NEQAS)
Implementing the kidney function risk equation - a laboratory perspective
Clinical Chemistry
Implementing the kidney function risk equation - a laboratory perspective
9.30am – 10am BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
This presentation will cover
- What is the kidney function risk equation and how is it used?
- What are the main challenges in implementing the kidney function risk equation in your LIMS?
- What are the benefits of implementing the kidney function risk equation?
- Pilot outcomes and next steps.
Speakers
Susan Troup
Principal Clinical Scientist, South of Tyne & Wear Clinical Pathology Services
Nitrous Oxide: No laughing matter
Clinical Chemistry
Nitrous Oxide: No laughing matter
10.30am – 11am BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
Nitrous oxide or 'laughing gas' has become a popular recreational drug of abuse amongst the young in recent years. The debilitating effects of abuse are often not known by recreational users and may be under-recognised by health care professionals.
We report on the clinical presentation of a young woman who suffered severe neurological sequelae after long term nitrous oxide use. We address some of the common pitfalls in diagnosing nitrous-oxide induced B12-deficiency and consider recent NICE guideline recommendations.
Learning outcomes
Delegates will:
- Learn basic biochemistry of how recreational Nitrous Oxide effects B12 and the consequent pathology that manifests as potentially irreversible nerve damage and muscle weakness.
- Learn how MMA and HCY are useful addition tests and how Total b12 and Active B12 are not helpful in these patients.
- Learn how patients present and can be treated.
Speakers
Dr Amro Maarouf MRCP FRCPath
Specialist Registrar in Chemical Pathology and Metabolic Medicine , Black Country Pathology Services
Nitrazene opiods and xylazine
Clinical Chemistry
Nitrazene opiods and xylazine
11am – 11.30am BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Speakers
Micronutrients and the acute phase response
Clinical Chemistry
Micronutrients and the acute phase response
11.30am – 12pm BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Illicit medications – Welsh Emerging Drugs and identification of Novel Substances (WEDINOS)
Clinical Chemistry
Illicit medications – Welsh Emerging Drugs and identification of Novel Substances (WEDINOS)
2pm – 2.30pm BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Learning outcomes
Delegates will gain knowledge on:
- Illicit medications
- Internet drug purchases
- What is in them, and
- A guide to WEDINOS
Speakers
Ozempic and others (GLP-1 agonists)
Clinical Chemistry
Ozempic and others (GLP-1 agonists)
2.30pm – 3pm BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Learning outcomes
Speakers
Gliflozins and euglycaemic diabetic ketoacidosis
Clinical Chemistry
Gliflozins and euglycaemic diabetic ketoacidosis
3pm – 3.30pm BST, 25 September 2025 ‐ 30 mins
Clinical Chemistry
Abstract
The gliflozins are a group of drugs used in the treatment of diabetes that show clear improvements in glycaemic control and renal function as part of the treatment regimen for persons suffering from type 2 diabetes. A rare but important side effect is a euglycaemic diabetic ketoacidosis (EDKA). This talk will discuss the mechanism of action of these drugs, the development of EDKA and provide pointers for its laboratory diagnosis.
Learning outcomes
Delegates will understand:
- What are the glilozins
- mechanism of action
- clinical use
- Euglycaemic ketoacidosis (EDKA) and points to watch out for with patients suffering from EDKA
Speakers
Dr Nigel Brown FIBMS, FRCPath, MRSC
Consultant Clinical Biochemist, Northumbria Healthcare NHS Foundation Trust